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Low Expression of miR-491 Promotes Esophageal Cancer Cell Invasion by Targeting TPX2
Hongyan Niu1, Li Gong, Xiaofeng Tian
1Department of Clinical Laboratory, Huai'an Hospital Affiliated of Xuzhou Medical College and Huai'an Second People's Hospital, Huai'an, China.
Background/Aims:
MicroRNAs (miRNAs) have a key role in carcinogenesis and cancer development, but the role of miRNAs in the progression of esophageal cancer (EC) remains unclear.
Methods:
The TE-1 and Eca-109 EC cell lines were used. The expression of miR-491 and candidate gene TPX2 in EC samples (n=99) were detected by RT-PCR. The cells invasive ability was determined by transwell assay. The luciferase reporter assay was used to confirm the regulation mechanism.
Results:
A decreased expression of miR-491 was detected in the EC clinical samples compared with the corresponding adjacent tumor tissues. Aberrant expression of miR-491 regulated cells invasion and EMT markers. Furthermore, we verified that TPX2 was a target gene of miR-491.
Conclusions:
miR-491 may play a critical role in EC.
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