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Updated: Jul 10, 2026

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A Rabbit Model of Durable Transgene Expression in Jugular Vein to Common Carotid Artery Interposition Grafts
Published on: September 10, 2018
Sequential, free and Y internal thoracic artery grafts
A J Tector1, T M Schmahl, J D Crouch
1St. Luke's Medical Center, Midwest Heart Surgery Institute, Milwaukee, Wisconsin 53215.
European Heart Journal
|December 1, 1989
Summary
The internal thoracic artery (ITA) offers superior long-term survival compared to saphenous vein grafts in coronary artery bypass grafting (CABG). Utilizing multiple ITA grafts significantly improves patient outcomes, even in complex cases.
Area of Science:
- Cardiovascular Surgery
- Thoracic Surgery
- Vascular Grafting
Background:
- The internal thoracic artery (ITA) demonstrates superior long-term patency and durability compared to saphenous vein grafts (SVG).
- Coronary artery bypass grafting (CABG) outcomes are significantly influenced by graft survival rates.
- Improving long-term survival in CABG patients remains a critical clinical objective.
Purpose of the Study:
- To evaluate the efficacy of utilizing multiple internal thoracic artery (ITA) grafts in coronary artery bypass grafting (CABG).
- To assess the impact of multiple ITA anastomoses on long-term patient survival and graft patency.
Main Methods:
- Retrospective analysis of 718 patients undergoing CABG with three or more ITA anastomoses since 1982.
- Implementation of techniques to optimize initial ITA graft flow, including careful pedicle preparation and specific anastomosis construction.
- Inclusion of diverse patient cohorts, including elderly individuals, those with left ventricular dysfunction, and emergency cases.
Main Results:
- Actuarial survival at 6 years reached 92.5% in the cohort receiving multiple ITA grafts.
- The study highlights the critical importance of initial graft flow for successful ITA utilization.
- Specific surgical techniques were employed to maximize critical flow and graft success.
Conclusions:
- The use of multiple internal thoracic artery (ITA) grafts in CABG is associated with excellent long-term survival rates.
- Careful surgical technique to ensure optimal graft flow is paramount for the success of ITA grafting.
- Multiple ITA grafting represents a durable and effective strategy for improving outcomes in coronary artery bypass surgery.

