Evaluation of Selective Arterial Embolization Effect by Chitosan Micro-Hydrogels in Hindlimb Sarcoma Rodent Models
Tai Kyoung Lee1, JeongIl Kwon2, Kyung Sook Na1
1Department of Nuclear Medicine, Research Institute of Clinical Medicine, Cyclotron Research Center, Institute for Medical Sciences, Molecular Imaging & Therapeutic Medicine Research Center Chonbuk National University Medical School and Hospital, Geumam-ro, Dukjin-gu, Jeonju, Republic of Korea.
Purpose:
Embolization is mainly used to reduce the size of locally advanced tumors. In this study, selective arterial catheterization with chitosan micro-hydrogels (CMH) into the femoral artery was performed and the therapeutic effect was validated using different imaging methods.
Methods:
Male SD rats (n = 18, 6 weeks old) were randomly assigned into three groups: Group 1 as control, Group 2 without any ligation of distal femoral artery, and Group 3 with temporary ligation of the distal femoral artery. RR1022 sarcoma cell lines were inoculated into thigh muscle. After 1 week, CMH was injected into the proximal femoral artery. Different imaging modalities were performed during a 3-week follow-up.
Results:
The tumor size was significantly (P < 0.001) decreased in both Group 2 and Group 3 (P < 0.001) after selective arterial embolization therapy. (18)F-FDG-PET/CT revealed decreased intensity of (18)F-FDG uptake in tumors. The accumulation status of (125)I-CMH near the tumor was verified by gamma camera.
Conclusions:
Appropriate selective arterial embolization therapy with CMH was.
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