Related Experiment Video
Updated: Apr 5, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Body Mass Index, High-Sensitivity C-Reactive Protein and Mortality in Chinese with Coronary Artery Disease
Ding Ding1, Min Wang1, Dongfang Su1
1Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Insights
Body Mass Index (BMI) and high-sensitivity C-reactive protein (hsCRP) show combined risks for mortality in coronary artery disease patients. Elevated hsCRP modifies the association between BMI and death, highlighting inflammation
Area of Science:
- Cardiology
- Biomarkers
- Public Health
Background:
- Investigating the independent and combined effects of Body Mass Index (BMI) and high-sensitivity C-reactive protein (hsCRP) on mortality risk.
- Examining the prognostic value of these markers in patients with established coronary artery disease (CAD).
Purpose of the Study:
- To determine the single and joint associations of BMI and hsCRP with all-cause and cardiovascular disease (CVD) mortality.
- To explore how hsCRP levels modify the relationship between BMI and mortality outcomes in CAD patients.
Main Methods:
- Utilized Cox regression models to analyze data from 1871 CAD patients (aged 40-85).
- Assessed associations of baseline BMI and serum hsCRP with mortality over a 3.1-year follow-up period.
- Adjusted for major cardiovascular risk factors during analysis.
Main Results:
- A J-shaped association was observed between BMI and both all-cause and CVD mortality.
- Elevated hsCRP (≥3.0 mg/L) was positively associated with mortality.
- Obese patients (BMI≥28 kg/m2) with elevated hsCRP had a 3.41-fold increased risk of all-cause mortality and 3.50-fold risk of CVD mortality compared to overweight patients with normal hsCRP.
- Lean patients (BMI<24 kg/m2) with elevated hsCRP also showed increased mortality risks.
Conclusions:
- The relationship between BMI and mortality risk is influenced by hsCRP levels.
- Low-grade inflammation, indicated by hsCRP, may play a role in the association between BMI and prognosis in CAD patients.
- These findings suggest that hsCRP is a critical factor in understanding BMI-related mortality risks in cardiovascular disease.
Background:
To investigate single and joint associations of body mass index (BMI) and serum high-sensitivity C-reactive protein (hsCRP) with death.
Methods:
The study included 1871 coronary artery disease (CAD) patients aged 40-85 year-old recruited from 2008 to 2011. Cox regression models were used to estimate the association of BMI and hsCRP with mortality. The data was analyzed in 2014.
Results:
During 3.1 years follow-up, 141 deaths were recorded, 110 died of cardiovascular disease (CVD). After adjustment of major CVD risk factors, there was a J-shaped association between BMI and all-cause and CVD mortality, and a positive association between hsCRP and mortality. The J-shaped association of BMI with mortality was present among patients who never smoked or with elevated hsCRP (≥3.0 mg/L). Compared with overweight (BMI 24-27.9 kg/m2) patients with normal hsCRP (<3.0 mg/L), obese patients (BMI≥28 kg/m2) with elevated hsCRP had a 3.41-fold risk of all-cause mortality (95% CI 1.49-7.80) and a 3.50-fold risk of CVD mortality (1.40-8.75), lean patients (BMI<24 kg/m2) with elevated hsCRP concentration had a 2.54-fold risk of all-cause mortality (1.36-4.74) and a 2.36-fold risk of CVD mortality (1.19-4.70).
Conclusions:
The association pattern between baseline BMI and mortality changed among different baseline hsCRP concentrations, indicating that low-grade inflammation may be related to BMI and secondary prognosis of CAD.
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:26Coronary Artery Disease IV: Preventive Measures
01:30Coronary Artery Disease I: Introduction
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:30Acute Coronary Syndrome III: Diagnostic Studies