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An atomic structure of human γ-secretase

Xiao-Chen Bai1, Chuangye Yan2, Guanghui Yang2

  • 1MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.

Nature
|August 18, 2015
PubMed
Summary

The atomic structure of human gamma-secretase (γ-secretase), crucial in Alzheimer's disease, reveals mutations affecting presenilin 1 (PS1) hotspots. This provides a molecular basis for understanding enzyme function and disease mechanisms.

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