Related Experiment Video
Updated: Apr 5, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
A population-based study on the associations between chronic periodontitis and the risk of cancer
Shiu-Dong Chung1, Ming-Chieh Tsai2, Chung-Chien Huang3
1Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, Ban Ciao, Taipei, Taiwan.
Background:
To date, the associations between chronic periodontitis (CP) and cancer lack large-scale population-based epidemiological evidence. This study aimed to investigate the subsequent risk for cancers among subjects with CP.
Methods:
This study cohort included 40,140 subjects with CP and 40,140 subjects who were matched for a comparison cohort. We individually tracked each patient for a 5-year period following their index date to identify those who had received a diagnosis of cancer.
Results:
The incidence rate of cancer during the 5-year follow-up period was 14.80 (95 % CI 14.28-15.34) per 1,000 person-years in subjects with CP. Cox proportional hazards regression revealed that the hazard ratio of cancer during the 5-year follow-up period for subjects with CP was 1.23 (95 % CI 1.20-1.27) compared to that of the comparison cohort.
Conclusion:
We observed an increased risk for the subsequent development of a number of cancers among subjects with CP.
Related Concept Videos
Cancer Prevention
Some...
Cancer Prevention
Observational Studies
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
Longitudinal Research
Psychoneuroimmunology: Diabetes and Cancer
Cancer Survival Analysis

