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[MORPHOFUNCTIONAL CONDITION OF THE UPPER GASTROINTESTINAL TRACT IN CHILDREN WITH OBESITY]

T A Bokova, A S Koshurnikova, N A Korsakova

    Eksperimental'Naia I Klinicheskaia Gastroenterologiia = Experimental & Clinical Gastroenterology
    |August 19, 2015
    PubMed

    Insights

    Children with obesity experience more upper gastrointestinal tract (UGIT) issues, including motor-evacuation disorders and inflammatory conditions like H. pylori-associated gastritis, compared to normal-weight children.

    Area of Science:

    • Pediatric Gastroenterology
    • Obesity Research
    • Gastrointestinal Physiology

    Background:

    • Childhood obesity is a growing global health concern.
    • Obesity is associated with various comorbidities, including gastrointestinal dysfunction.
    • The morphofunctional state of the upper gastrointestinal tract (UGIT) in obese children requires further characterization.

    Purpose of the Study:

    • To investigate the characteristics of the morphofunctional state of the UGIT in children with obesity.
    • To compare UGIT disorders in obese children versus normal-weight children.
    • To identify specific inflammatory and functional changes in the UGIT of obese pediatric populations.

    Main Methods:

    • A study involving 130 children aged 10-16 years.
    • Comparison between a study group of 80 obese children (SDS BMI ≥ 2.0) and a control group of 50 normal-weight children (SDS BMI -0.99 to +0.99).
    • Assessment of upper gastrointestinal tract diseases and disorders.

    Main Results:

    • Obese children exhibited a higher frequency of isolated motor-evacuation disorders (6.3% vs. 2.0%) compared to normal-weight children.
    • Combinations of inflammatory and functional UGIT disorders were more prevalent in obese children (48.8% vs. 38.0%).
    • Functional UGIT changes in obese children included frequent motor disorders and active chronic gastritis associated with H. pylori (58.3%), often with minimal symptoms and focal inflammation.

    Conclusions:

    • Children with obesity demonstrate a significantly altered morphofunctional state of the upper gastrointestinal tract.
    • Motor and inflammatory disorders, including H. pylori-related gastritis, are more common in obese children.
    • These findings highlight the need for targeted gastrointestinal assessments in pediatric obesity management.

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