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[Hemodynamic effects of succinate-containing dialyzing solution].

A V Smirnov1, R V Golubev1, A N Vasiliev1

  • 1Research Institute of Nephrology, Acad. I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia, Saint Petersburg, Russia.

Terapevticheskii Arkhiv
|August 19, 2015
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Acetate-free succinate-containing dialysate (SDS) use in hemodialysis (HD) patients lowered blood sodium and improved blood pressure control. This HD solution also reduced interdialytic weight gain and prevented hypotension during treatment.

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Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Biochemistry

Context:

  • Chronic hemodialysis (HD) patients often experience fluid and electrolyte imbalances.
  • Managing natremia and blood pressure (BP) is crucial in HD patients.
  • Acetate-free dialysates are alternatives to traditional solutions.

Purpose:

  • To evaluate the impact of succinate-containing dialysate (SDS) on natremia and BP in chronic HD patients.
  • To assess changes in biochemical indicators, BP, and weight during HD treatment with SDS.

Summary:

  • A 3-month study involving 92 HD patients using SDS showed statistically significant decreases in pre-dialysis blood sodium and systolic BP.
  • Patients experienced reduced interdialytic weight gain, and a trend towards fewer hypertensive episodes was observed.
  • SDS use led to improved hypertension control and prevented hypotension during HD sessions.

Impact:

  • SDS demonstrates potential for improving fluid management and cardiovascular stability in HD patients.
  • This dialysate may offer benefits in managing hypertension and preventing intradialytic hypotension.
  • Findings suggest SDS as a viable alternative dialysate for optimizing HD treatment outcomes.