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[Meta-analysis of clinical trials of cardiovascular effects of magnesium orotate]

I Yu Torshin1, O A Gromova2, A G Kalacheva2

  • 1Moscow Institute of Physics and Technology, Dolgoprudnyi, Russia.

Terapevticheskii Arkhiv
|August 19, 2015
PubMed

Insights

Magnesium orotate (magnerot) shows significant promise for cardiac patients, reducing risks of hypomagnesemia, arrhythmias, and hypertension. This meta-analysis confirms its benefits in preventing and treating various cardiovascular conditions.

Area of Science:

  • Cardiology
  • Nutritional Science
  • Pharmacology

Context:

  • Cardiac patients often experience various pathological conditions.
  • Magnesium deficiency (hypomagnesemia) is a known risk factor for cardiovascular issues.
  • Magnesium orotate is a compound used for its potential therapeutic effects in heart conditions.

Purpose:

  • To conduct a meta-analysis of randomized trials evaluating the efficacy of magnerot (magnesium orotate) in cardiac patients.
  • To assess the impact of magnerot on the risk of 50 pathological conditions in a cardiac population.

Summary:

  • This meta-analysis synthesized data from 19 randomized trials involving 603 patients treated with magnerot and 587 on placebo.
  • Magnerot administration was significantly associated with a reduced risk of hypomagnesemia, exercise intolerance, dysautonomia, headaches, dizziness, mitral valve prolapse, premature contractions, and hypertension.
  • The study highlights magnerot's potential in managing arrhythmias, blood pressure, and autonomic nervous system function.

Impact:

  • Magnesium orotate demonstrates significant potential in treating and preventing a range of cardiovascular conditions.
  • The findings suggest magnerot can be a valuable therapeutic agent for cardiac patients, addressing hypomagnesemia and improving cardiac function.
  • This research supports the use of magnesium orotate for comprehensive cardiovascular health management.
Abstract

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