[Kidney injury associated with monoclonal gammopathies: Perspectives on diagnosis and treatment]
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Published on: August 23, 2024
L V Kozlovskaya1, V V Rameev1, N N Mrykhin1
1I.M. Sechenov First Moscow Medical University, Ministry of Health of Russia, Moscow, Russia.
Abstract:
It is currently well justified that monoclonal gammopathies are the most important predictor for kidney diseases, including glomerulonephritis. To determine a correlation of nephropathy with oligosecretory gammopathy is of fundamental importance, as the treatment of these patients necessitates the use of special chemotherapy regimens to eliminate a pathological clone of lymphocytes or plasmocytes. If this clone is not eliminated, injury of the organ may recur to develop its failure. The principles of this therapy have been presently tried out by the example of AL-amyloidosis and showed its efficiency and relatively low toxicity.
Insights
Monoclonal gammopathies predict kidney diseases. Determining the link between nephropathy and oligosecretory gammopathy is crucial for effective chemotherapy to prevent organ failure.
Area of Science:
- Nephrology
- Hematology
- Oncology
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