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Articles linked to this work by shared authors, journal, and citation graph.

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ERK1/2 inhibition increases dopamine release from differentiated PC12 cells.

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Analysis of ERK1/2 kinases in the inferior colliculus of rats genetically prone to audiogenic seizures during postnatal development.

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[THE INVESTIGATION OF VASOPRESSIN SECRETION IN NORMAL CONDITION AND DURING SEIZURE ONSET IN KRUSHINSKY-MOLODKINA RATS].

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[MOLECULAR MECHANISMS OF ERK1/2 KINASES REGULATION IN THE GLUTAMATE- AND GABA-ERGIC NEURONS DURING SEIZURE EXPRESSION IN KRUSHINSKY-MOLODKINA RATS].

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova·2016

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[COMPARATIVE STUDY OF NIGROSTRIATAL SYSTEMS IN WISTAR RATS AND RATS PRONE TO SEIZURES].

N A Dorofeeva, M V Glazova, K A Khudik

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    |August 19, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Krushinsky-Molodkina (KM) rats prone to audiogenic seizures exhibit disrupted dopaminergic and GABA-ergic neuron activity. This imbalance in the nigrostriatal system may contribute to their heightened convulsive susceptibility.

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    Area of Science:

    • Neuroscience
    • Neurochemistry
    • Seizure Disorders

    Context:

    • The nigrostriatal system plays a crucial role in motor control and reward pathways.
    • Krushinsky-Molodkina (KM) rats are a genetic model exhibiting audiogenic seizures.
    • Understanding neurotransmitter system imbalances is key to addressing seizure disorders.

    Purpose:

    • To investigate the functional activity of dopaminergic, GABA-ergic, and glutamatergic neurons in the nigrostriatal system of KM rats.
    • To identify neurochemical alterations associated with audiogenic seizure proneness in KM rats.
    • To explore the relationship between neurotransmitter dysregulation and seizure susceptibility.

    Summary:

    • Analysis revealed disturbed GABA-ergic and dopaminergic neuron activity in the substantia nigra of KM rats, with unchanged glutamatergic neurotransmission.
    • Elevated D1 dopamine receptors and decreased D2 receptors in KM rats may upregulate glutamatergic neurotransmission, evidenced by increased VGlut2 and NR2B expression.
    • Increased ERK1/2 activity and enhanced exocytosis (downregulated SNAP25) in KM rats suggest hyperactive glutamatergic signaling, potentially linked to seizure susceptibility.

    Impact:

    • Identifies specific neurotransmitter system dysfunctions in a rat model of audiogenic seizures.
    • Suggests that impaired dopaminergic and GABA-ergic inhibition contributes to glutamatergic hyperactivity and seizures.
    • Provides insights into potential therapeutic targets for seizure disorders by highlighting the role of the nigrostriatal system.