Comparative study of the effects of cimetropium bromide and atropine on human esophageal motor functions

The effects of atropine and cimetropium bromide, a new antimuscarinic compound with strong spasmolytic properties, were studied on human esophageal motility. Twenty healthy subjects underwent esophageal manometry with continuous monitoring of lower esophageal sphincter pressure (LESP), and of amplitude, duration and velocity of contractions of the esophageal body. After a 30-min basal period, atropine (12 micrograms/kg) or cimetropium (5 mg) were administered as an intravenous bolus in a cross-over random manner and the recording was continued for another 60 min. Twenty minutes after injection, atropine and cimetropium decreased maximally, in a similar extent, both the amplitude of contractions of the esophageal body (-65% of the basal values) and the LESP (-30% of the basal values). The duration and propagation velocity of the esophageal contractions did not change significantly after both drugs. Sixty minutes after injection of cimetropium, the amplitude of contractions of the esophageal body and LESP returned to basal values while atropine still reduced both variables. These findings indicate that cimetropium bromide has an inhibitory effect on LESP and on the amplitude of contractions of the esophageal body similar to atropine, but its action lasts less time.