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Platelet function in dogs with bacterial infections and leishmaniasis
Berliner Und Munchener Tierarztliche Wochenschrift
|August 19, 2015
Summary
Bacterial infections and leishmaniasis in dogs can affect primary hemostasis, leading to altered platelet function. Most in vitro tests showed normal to reduced platelet aggregability, suggesting potential preactivation.
Area of Science:
- Veterinary Medicine
- Hematology
- Infectious Diseases
Background:
- Primary hemostasis is crucial for blood clotting.
- Bacterial infections and leishmaniasis can impact canine health.
- Platelet function is a key component of hemostasis.
Purpose of the Study:
- To investigate the effects of bacterial infections or leishmaniasis on primary hemostasis in dogs.
- To compare platelet function in infected dogs with a control group.
- To analyze differences based on the presence of systemic inflammatory response syndrome (SIRS).
Main Methods:
- Evaluated capillary bleeding time, platelet count, and hematocrit.
- Utilized automatic platelet function analysis (PFA-100).
- Performed turbidimetric platelet aggregation and impedance aggregometry.
Main Results:
- Dogs with infections showed prolonged PFA-100 closure times.
- Maximal platelet aggregation decreased significantly in turbidimetric analysis.
- Impedance aggregometry revealed increased collagen-induced and suppressed arachidonic acid-induced aggregation.
- Enhanced collagen-induced aggregation was noted in SIRS subgroup.
Conclusions:
- Infections in dogs can alter primary hemostasis and platelet function.
- While some tests suggest enhanced aggregation, most in vitro results indicate normal to reduced functionality.
- Reduced platelet aggregability may be linked to preactivation of platelets in infected dogs.
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