Related Experiment Video

Updated: Apr 5, 2026

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs
10:13

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs

Published on: November 8, 2024

3.0K

[Fragmentation pathways of five furocoumarine using line ion trap with orbitrapmass spectrometry]

Xu-guang Wang, Hong-jun Yang, Song-song Wang

    Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
    |August 19, 2015
    PubMed
    Abstract

    More Related Videos

    Standardized Identification of Compound Structure in Tibetan Medicine Using Ion Trap Mass Spectrometry and Multiple-Stage Fragmentation Analysis09:24

    Standardized Identification of Compound Structure in Tibetan Medicine Using Ion Trap Mass Spectrometry and Multiple-Stage Fragmentation Analysis

    Published on: March 17, 2023

    1.4K
    Untargeted Metabolomics from Biological Sources Using Ultraperformance Liquid Chromatography-High Resolution Mass Spectrometry UPLC-HRMS11:00

    Untargeted Metabolomics from Biological Sources Using Ultraperformance Liquid Chromatography-High Resolution Mass Spectrometry UPLC-HRMS

    Published on: May 20, 2013

    23.6K

    Related Concept Videos

    Mass Spectrometry: Aromatic Compound Fragmentation01:23

    Mass Spectrometry: Aromatic Compound Fragmentation

    Upon ionization, aromatic compounds generate a molecular ion that is observed as a prominent peak in their mass spectra. For example, the molecular ion peak for benzene appears at a mass-to-charge ratio of 78, while toluene is observed at a mass-to-charge ratio of 92. The molecular ion benzene is highly stable and does not readily undergo further fragmentation due to the significant amount of energy required to disrupt the aromatic stability of the benzene ring. In contrast, the molecular ion...
    2.7K
    Mass Spectrometry: Branched Alkane Fragmentation01:29

    Mass Spectrometry: Branched Alkane Fragmentation

    This lesson delves into the mass spectrometry of branched alkane fragmentation. Branched alkanes possess secondary or tertiary carbon atoms, which generate relatively stable carbocations if the cleavage occurs at the branching point. The high stability of carbocations drives the instant fragmentation of branched alkanes. Accordingly, the branched alkane's molecular ion peak is very weak or invisible in the mass spectra, especially in comparison to a linear alkane.
    2.0K
    Mass Spectrometry: Molecular Fragmentation Overview01:20

    Mass Spectrometry: Molecular Fragmentation Overview

    The ionization of a molecule into a molecular ion inside the mass spectrometer causes instability in the molecule's structure due to the loss of an electron. This eventually leads to the fragmentation or breaking of some bonds in the molecule. The fragmentation occurs predominantly at specific bonds to yield relatively stable fragments.
    One type of fragmentation pattern is the cleavage of a single bond in the molecular ion. The cleavage leads to a radical and a cation. The cleavage can occur at...
    6.6K
    Mass Spectrometry: Cycloalkane Fragmentation01:05

    Mass Spectrometry: Cycloalkane Fragmentation

    In mass spectrometry, cycloalkanes exhibit distinct fragmentation patterns due to the inherent stability of their molecular ions compared to linear or branched alkanes. The ring structure of cycloalkanes provides additional stability to the molecular ions, often resulting in prominent ion peaks in the mass spectrum.
    For example, cyclohexane molecular ions have a mass-to-charge ratio (m/z) of 84, which tends to produce a stronger signal than linear alkanes like hexane. This stability comes from...
    2.5K
    Mass Spectrometry: Cycloalkene Fragmentation00:54

    Mass Spectrometry: Cycloalkene Fragmentation

    The molecular ions of cycloalkenes undergo fragmentation via a retro-Diels–Alder reaction.
    1.7K
    Mass Spectrometry: Carboxylic Acid, Ester, and Amide Fragmentation01:01

    Mass Spectrometry: Carboxylic Acid, Ester, and Amide Fragmentation

    The fragmentation patterns observed for compounds such as carboxylic acids, esters, and amides in the mass spectra include ⍺-cleavage and McLafferty rearrangement. Fragmentation by ⍺-cleavage preferentially occurs at the carbon-carbon bond at the ⍺-position next to the carboxylic group to generate a neutral radical and a cation. Long chain compounds with hydrogen at their γ-carbon undergo McLafferty rearrangement to give a radical cation and a neutral alkene.
    For example, the...
    2.8K