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Lipidomics and Transcriptomics in Neurological Diseases
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Cannabinoids and Epilepsy.

Evan C Rosenberg1, Richard W Tsien1, Benjamin J Whalley2

  • 1Department of Neuroscience and Physiology, Neuroscience Institute, NYU Langone Medical Center, New York, NY, 10016, USA.

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics
|August 19, 2015
PubMed
Summary
This summary is machine-generated.

Cannabidiol (CBD) shows promise as a well-tolerated antiepileptic therapy, unlike whole-plant cannabis which has mixed effects on seizures. This review explores cannabinoids for epilepsy treatment.

Keywords:
EpilepsyTHCcannabidiolcannabinoidscannabisseizures

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Epileptology

Background:

  • Cannabis has historical use for seizure management.
  • Emerging data suggest cannabinoids, including cannabidiol (CBD), may offer therapeutic benefits for epilepsy.
  • Understanding the endocannabinoid system is crucial for evaluating cannabis-based therapies.

Purpose of the Study:

  • To review the endocannabinoid system's role in epilepsy.
  • To characterize the effects of cannabinoids like Δ9-tetrahydrocannabinol and CBD on seizures.
  • To evaluate scientific evidence for cannabinoids in epilepsy treatment.

Main Methods:

  • Review of pre-clinical and clinical studies on cannabinoids in epilepsy.
  • Analysis of mechanistic insights into cannabinoid action.
  • Discussion of a new multicenter, open-label study using CBD for treatment-resistant epilepsy.

Main Results:

  • CBD appears to be a well-tolerated antiepileptic agent, lacking psychoactive effects.
  • Whole-plant cannabis exhibits variable effects, potentially both causing and reducing seizures.
  • Preliminary results from a new CBD study in treatment-resistant epilepsy are discussed.

Conclusions:

  • CBD presents a promising therapeutic option for seizure management.
  • Further basic science and clinical research are needed to optimize cannabinoid-based epilepsy treatments.
  • The differential effects of CBD versus whole-plant cannabis warrant further investigation.