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Peritoneal dialysis as a treatment option in autosomal dominant polycystic kidney disease

Magdalena Jankowska1, Michał Chmielewski2, Monika Lichodziejewska-Niemierko2

  • 1Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, ul. Dębinki 7, 81-211, Gdańsk, Poland. maja@gumed.edu.pl.

International Urology and Nephrology
|August 19, 2015
PubMed

Insights

Peritoneal dialysis (PD) is a viable option for Autosomal Dominant Polycystic Kidney Disease (ADPKD) patients. While ADPKD patients had a higher risk of hernias and leaks, dialysis adequacy and survival rates were similar to non-ADPKD patients.

Area of Science:

  • Nephrology
  • Renal Replacement Therapy

Background:

  • Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic disorder.
  • Peritoneal dialysis (PD) is often avoided in ADPKD due to perceived risks.
  • Limited comparative data exists for PD in ADPKD patients.

Purpose of the Study:

  • To compare dialysis adequacy and outcomes in ADPKD patients undergoing PD versus non-ADPKD patients.
  • To evaluate the safety and efficacy of PD as a treatment for end-stage renal disease in ADPKD.

Main Methods:

  • Retrospective analysis of a national PD registry.
  • Inclusion of 106 ADPKD and 1606 non-ADPKD incident PD patients.
  • Comparison of dialysis adequacy, complication rates, and survival between groups.

Main Results:

  • No significant difference in dialysis adequacy between ADPKD and non-ADPKD groups.
  • Similar patient and technique survival rates after a median follow-up of 32 months.
  • ADPKD patients exhibited a twofold higher risk of abdominal hernias and fluid leaks, without necessitating permanent hemodialysis transfer.

Conclusions:

  • Peritoneal dialysis demonstrates comparable efficacy and survival to non-ADPKD patients.
  • Despite increased risk of specific complications, PD is a feasible treatment for ADPKD patients with end-stage renal failure.
Abstract

Keywords:
Peritoneal dialysisPolycystic kidney diseaseRegistry

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