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A plasmonic nanosensor with inverse sensitivity for circulating cell-free DNA quantification.

Roger M Pallares1, Say Li Kong, Tan Hui Ru

  • 1Department of Chemistry, University College London, London, WC1H 0AJ, UK.

Chemical Communications (Cambridge, England)
|August 19, 2015
PubMed
Summary

This study introduces a novel plasmonic nanosensor for quantifying cell-free DNA. The sensor exhibits inverse sensitivity, where lower DNA concentrations yield higher signals due to nanoparticle aggregation.

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Analytical Chemistry

Background:

  • Circulating cell-free DNA (cfDNA) is a valuable biomarker in various medical applications.
  • Accurate and sensitive quantification of cfDNA remains a challenge.
  • Plasmonic nanosensors offer potential for sensitive biomolecule detection.

Purpose of the Study:

  • To develop a plasmonic nanosensor for quantifying circulating cell-free DNA.
  • To achieve inverse sensitivity for enhanced detection at low concentrations.
  • To establish a tunable assay for cfDNA quantification.

Main Methods:

  • Utilized gold nanorods as the core component of the plasmonic nanosensor.
  • Investigated DNA concentration-dependent aggregation of gold nanorods.
  • Explored the relationship between nanoparticle concentration and assay dynamic range.

Main Results:

  • Demonstrated a plasmonic nanosensor with inverse sensitivity for cfDNA.
  • Observed unusual DNA concentration-dependent aggregation of gold nanorods.
  • Showcased the ability to adjust the assay's dynamic range by controlling nanoparticle concentration.

Conclusions:

  • The developed plasmonic nanosensor provides a novel approach for cfDNA quantification.
  • The inverse sensitivity mechanism offers advantages for detecting low cfDNA levels.
  • This method presents a tunable and sensitive platform for biomarker analysis.