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Longitudinal Andhra Pradesh Eye Disease Study: rationale, study design and research methodology
Rohit C Khanna1,2, Gudlavalleti Vs Murthy3,4, Srinivas Marmamula1,2
1Allen Foster Community Eye Health Research Centre, Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye Care, L V Prasad Eye Institute, Banjara Hills, India.
Clinical & Experimental Ophthalmology
|August 19, 2015
Summary
This longitudinal study tracks visual impairment and eye diseases in rural India. Findings will inform eye care planning and highlight risk factors for conditions like glaucoma and macular degeneration.
Area of Science:
- Ophthalmology and Public Health Research
- Longitudinal Cohort Studies in India
Background:
- The Andhra Pradesh Eye Disease Study (APEDS) established baseline data for eye conditions in rural and urban populations.
- A longitudinal design is crucial for understanding disease progression and incidence over time.
Purpose of the Study:
- To describe the rationale, objectives, and design of the Andhra Pradesh Eye Disease Study 3 (APEDS3), a longitudinal follow-up.
- To collect comprehensive data on sociodemographic factors, ocular and systemic history, and risk factors for eye diseases.
- To assess visual function, knowledge of eye diseases, and barriers to accessing eye care services.
Main Methods:
- A longitudinal cohort study involving participants from the rural component of the original Andhra Pradesh Eye Disease Study.
- APEDS3 includes detailed interviews and comprehensive eye examinations, including lens, optic disc, and retinal photography, OCT, anthropometry, blood pressure, and frailty measures.
- Data collection focuses on incidence and progression of visual impairment, age-related eye diseases (lens opacities, glaucoma, AMD), and associated risk factors.
Main Results:
- Of 7771 participants in the initial rural Andhra Pradesh Eye Disease Survey (APEDS1), 5447 (70.1%) were successfully traced for APEDS2.
- These traced participants will undergo re-examination in APEDS3 to assess disease progression and incidence.
Conclusions:
- APEDS3 will yield critical data on the incidence and progression of visual impairment and major eye diseases in India.
- The study's findings will provide essential evidence for planning effective eye care services and interventions in the region.
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