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Regulatory T-Cell Development in the Human Thymus

Íris Caramalho1, Helena Nunes-Cabaço1, Russell B Foxall1

  • 1Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa , Lisbon , Portugal.

Frontiers in Immunology
|August 19, 2015
PubMed
Summary

Regulatory T-cells (Tregs) develop in the thymus, requiring specific interactions for self-tolerance. This review explores human thymic Treg differentiation, molecular signals, and cellular interactions crucial for immune regulation.

Keywords:
FOXP3human thymic defectshuman thymusprimary immunodeficiencyregulatory T-cell developmentregulatory T-cells

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