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Updated: Apr 5, 2026
Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
Published on: March 25, 2019
A Quick Responsive Fluorogenic pH Probe for Ovarian Tumor Imaging
Ching-Hsuan Tung1, Jianjun Qi2, Lingchuan Hu2
11. Department of Translational Imaging, Houston Methodist Research Institute; ; 2. Department of Obstetrics and Gynecology, Houston Methodist Hospital, Houston, TX, USA ; 3. Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medical College, New York, NY, USA.
Abstract:
A novel cell-permeable compound, CypH-1, that is non-fluorescent at neutral pH, but fluoresces under mildly acidic conditions with a near infrared maximum emission wavelength was designed for the detection of tumors in the clinical setting. The potential of CypH-1 in ovarian cancer imaging was demonstrated using a murine model. The intraperitoneally administered CypH-1 results in a robust fluorescence signal of discrete neoplastic lesions with millimeter range resolution within few hours. Moreover, fluorescence signal is strikingly enhanced at peripheral regions of tumors at the microscopic level suggesting a sharp physiological difference at the tumor/normal tissue interface. This robust acid-activated imaging agent is expected to have significant impact in broad surgical and diagnostic applications.
