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A Quick Responsive Fluorogenic pH Probe for Ovarian Tumor Imaging.

Ching-Hsuan Tung1, Jianjun Qi2, Lingchuan Hu2

  • 11. Department of Translational Imaging, Houston Methodist Research Institute; ; 2. Department of Obstetrics and Gynecology, Houston Methodist Hospital, Houston, TX, USA ; 3. Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medical College, New York, NY, USA.

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Summary
This summary is machine-generated.

A new near-infrared fluorescent compound, CypH-1, detects ovarian tumors in mice under acidic conditions. This acid-activated imaging agent shows promise for clinical tumor detection and surgical guidance.

Keywords:
acidicfluorogenic dyeovarian cancer.pH indicatortumor microenvironment

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Area of Science:

  • Biomedical imaging
  • Chemical biology
  • Oncology

Background:

  • Early and accurate tumor detection remains a clinical challenge.
  • Novel imaging agents are needed to improve diagnostic capabilities.
  • Tumor microenvironments often exhibit distinct physiological properties, such as acidity.

Purpose of the Study:

  • To design and evaluate a novel cell-permeable, pH-sensitive fluorescent compound for tumor imaging.
  • To assess the efficacy of CypH-1 in detecting ovarian cancer in a preclinical murine model.
  • To investigate the fluorescence characteristics and tumor-to-normal tissue contrast of CypH-1.

Main Methods:

  • Design of CypH-1, a near-infrared emitting compound activated by mildly acidic conditions.
  • Administration of CypH-1 to a murine model of ovarian cancer.
  • Intraperitoneal injection and subsequent fluorescence imaging of tumor-bearing mice.
  • Microscopic analysis of fluorescence distribution at the tumor-normal tissue interface.

Main Results:

  • CypH-1 is non-fluorescent at neutral pH but exhibits strong fluorescence under mildly acidic conditions.
  • Intraperitoneal administration of CypH-1 yielded robust fluorescence signals from discrete neoplastic lesions with millimeter resolution within hours.
  • Enhanced fluorescence was observed at the peripheral regions of tumors, indicating physiological differences at the tumor/normal tissue interface.

Conclusions:

  • CypH-1 is a promising acid-activated imaging agent for detecting ovarian tumors.
  • Its ability to generate strong signals in acidic tumor microenvironments suggests broad applicability in surgical and diagnostic settings.
  • The compound's near-infrared emission and high resolution offer potential advantages for clinical imaging.