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Clindamycin Phosphate Absorption from Nanoliposomal Formulations through Third-Degree Burn Eschar
Azadeh Ghaffari1, Ali Manafi2, Hamid Reza Moghimi3
1Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran; ; Department of Food and Drug Control, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran;
World Journal of Plastic Surgery
|August 19, 2015
Summary
Nanoliposomes reduce clindamycin phosphate (CP) absorption through burn eschar, similar to normal skin. This suggests potential CP deposition within the eschar tissue for improved burn healing.
Area of Science:
- Pharmacology
- Dermatology
- Materials Science
Background:
- Topical nanoliposomal formulations enhance burn healing.
- Liposomes increase drug deposition in normal skin and reduce systemic absorption.
- Data on liposomal drug permeation through burn eschar is lacking.
Purpose of the Study:
- To investigate clindamycin phosphate (CP) permeation through burn eschar from liposomal formulations.
- To compare CP permeation from solution, normal nanoliposomes, and ultradeformable nanoliposomes.
Main Methods:
- Liposomal CP formulations were prepared and characterized (size, zeta potential, stability).
- The effect of liposomal lipid concentration on CP absorption was evaluated.
- Permeation through third-degree burn eschar was assessed.
Main Results:
- Nanoliposomes showed a retardation effect on CP permeation through burn eschar.
- Increasing liposomal lipid concentration decreased CP permeation.
- No significant difference in CP absorption was observed between normal and ultradeformable nanoliposomes.
Conclusions:
- Nanoliposomes decrease trans-eschar absorption of CP, consistent with normal skin data.
- This suggests potential CP deposition within the burn eschar.
- Nanoliposomal formulations may be beneficial for topical burn treatment.
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