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Stem Cells and Their Mediators - Next Generation Therapy for Bronchopulmonary Dysplasia

Marius A Möbius1, Bernard Thébaud2

  • 1Department of Neonatology and Pediatric Critical Care Medicine, Medical Faculty, University Hospital Carl Gustav Carus, Technische Universität Dresden , Dresden , Germany ; DFG Research Center and Cluster of Excellence for Regenerative Therapies (CRTD), Technische Universität Dresden , Dresden , Germany ; Regenerative Medicine Program, Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, University of Ottawa , Ottawa, ON , Canada.

Frontiers in Medicine
|August 19, 2015
PubMed

Insights

Mesenchymal stromal, endothelial progenitor, and amniotic epithelial cells show therapeutic potential for bronchopulmonary dysplasia (BPD). Further research is needed to understand mechanisms and overcome challenges for clinical application in premature infants.

Area of Science:

  • Neonatal Medicine
  • Regenerative Medicine
  • Pulmonary Biology

Background:

  • Bronchopulmonary dysplasia (BPD) is a significant complication of premature birth with no current cure.
  • Advances in stem/progenitor cell biology offer potential for lung regeneration in BPD.
  • Current stem cell therapies for BPD are experimental, with limited understanding of their mechanisms and efficacy.

Purpose of the Study:

  • To review the therapeutic potential of specific stem/progenitor cells for BPD.
  • To summarize the mechanisms of action for stem cell therapies in BPD.
  • To discuss challenges and potential solutions for translating these therapies from research to clinical practice.

Main Methods:

  • Review of current literature on stem/progenitor cell therapies for BPD.
  • Analysis of experimental data from animal models and early clinical studies.
  • Discussion of biological mechanisms and clinical translation hurdles.

Main Results:

  • Mesenchymal stromal cells, endothelial progenitor cells, and amniotic epithelial cells demonstrate promise in preclinical BPD models.
  • Early clinical studies in infants with BPD have been initiated.
  • Limited knowledge exists regarding the precise mechanisms of action and efficacy prediction for these cell therapies.

Conclusions:

  • Stem/progenitor cell therapies hold significant potential for treating BPD.
  • Key challenges include understanding mechanisms, cell population heterogeneity, and lack of potency assays.
  • Overcoming these obstacles is crucial for successful clinical translation of regenerative therapies for BPD.

Keywords:
bronchopulmonary dysplasiacurrent good manufacturing practiceendothelial progenitor cellslungmesenchymal stromal cellspotency assaystem cells

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