Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MicroRNAs01:22

MicroRNAs

4.3K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.3K
MicroRNAs01:22

MicroRNAs

24.7K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

External validation of the prostatic inflammation nomogram to predict prostatic inflammation in men with lower urinary tract symptoms.

Minerva urology and nephrology·2026
Same author

Fra-2 controls the response to the KRAS inhibitor MRTX-1133 in pancreatic ductal adenocarcinoma.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

IL-33 expands plasma cells, disrupts germinal centers, and increases autoantibody production in mice.

Nature communications·2025
Same author

High-Throughput Molecular Characterization of the Microbiome in Breast Implant-Associated Anaplastic Large Cell Lymphoma and Peri-Implant Benign Seromas.

Cancers·2025
Same author

Trends in Thyroid Fine-Needle Aspiration Cytology - Results from the Italian Cytopathology Committee National Practice Survey.

Pathologica·2025
Same author

Lung and nodal hairy cell leukemia with concurrent infectious granulomatosis: a mimic of metastatic lung epithelial neoplasia.

Pathologica·2025
Same journal

Posterior capsule rupture with complete lens dislocation into the vitreous cavity caused by blunt trauma: a case report.

Frontiers in medicine·2026
Same journal

Case Report: Heparin resistance as the harbinger of heparin-induced thrombocytopenia in acute pulmonary embolism.

Frontiers in medicine·2026
Same journal

Trends and variation in use of end-tidal carbon dioxide during in-hospital cardiac arrest: an observational cohort study.

Frontiers in medicine·2026
Same journal

From virtual pregnancy to digital twin obstetrics: multimodal data integration for personalized prediction of pregnancy complications.

Frontiers in medicine·2026
Same journal

Immunotherapy with or without low-intensity chemotherapy versus conventional chemotherapy as first-line treatment for newly diagnosed B-ALL patients fit for intensive chemotherapy: a propensity score-matched study.

Frontiers in medicine·2026
Same journal

Hypertension and frailty in older adults: a bibliometric analysis and knowledge mapping based on Web of Science, Scopus, and PubMed (1973-2025).

Frontiers in medicine·2026
See all related articles

Related Experiment Video

Updated: Apr 5, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

512

microRNA: Diagnostic Perspective.

Omar Faruq1, Andrea Vecchione1

  • 1Division of Pathology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Ospedale Santo Andrea, Sapienza University of Rome , Rome , Italy.

Frontiers in Medicine
|August 19, 2015
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) show promise as superior diagnostic and prognostic biomarkers due to their high specificity and sensitivity. These small RNA molecules are stable, easily measurable, and implicated in various diseases, overcoming limitations of current biomarkers.

Keywords:
biomarkersdiagnosismicro-RNA

More Related Videos

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
08:14

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

Published on: October 26, 2017

16.3K
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

6.1K

Related Experiment Videos

Last Updated: Apr 5, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

512
MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
08:14

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

Published on: October 26, 2017

16.3K
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

6.1K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genomics

Background:

  • Current biomarkers often lack specificity, sensitivity, and can yield false positives.
  • Ideal biomarkers should be safe, cost-efficient, easily measurable, and consistent across diverse populations.

Purpose of the Study:

  • To review the emerging concepts and potential of microRNAs (miRNAs) as diagnostic and prognostic biomarkers.
  • To highlight the role of specific miRNAs in various diseases, including cancer, cardiovascular diseases, and diabetes.

Main Methods:

  • Review of existing literature on microRNA biology and their application as biomarkers.
  • Analysis of studies demonstrating miRNA stability, ease of measurement, and diagnostic potential.

Main Results:

  • MicroRNAs (miRNAs) are small, non-coding RNAs crucial for gene expression regulation.
  • miRNAs exhibit high specificity and sensitivity, making them effective diagnostic and prognostic tools.
  • miRNAs are stable and readily detectable in tissues and bodily fluids.

Conclusions:

  • MicroRNAs represent a promising class of biomarkers, overcoming limitations of traditional markers.
  • Specific miRNAs are associated with various diseases, offering potential for targeted diagnostics and prognostics.
  • Further research into miRNAs could revolutionize disease diagnosis and management across multiple fields.