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Related Experiment Video

Updated: Apr 5, 2026

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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Virus-specific T-cell therapy in solid organ transplantation.

Andy Roemhild1,2, Petra Reinke1,2

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Transplant International : Official Journal of the European Society for Organ Transplantation
|August 19, 2015
PubMed
Summary

This review explores T-cell therapy for virus-associated diseases post-solid organ transplantation (SOT). It summarizes clinical trials and manufacturing considerations for this promising treatment option.

Keywords:
Epstein-Barr virusT-cell therapygood manufacturing practiceshuman cytomegalovirussolid organ transplantationvirus-specific

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Area of Science:

  • Immunology
  • Transplantation Medicine
  • Virology

Background:

  • Solid organ transplantation (SOT) patients face significant risks from viral complications.
  • Standard treatment regimens for these viral infections have limitations.
  • T-cell therapy presents a potential alternative for managing these conditions.

Purpose of the Study:

  • To review the current status of T-cell therapy for virus-associated diseases in SOT recipients.
  • To summarize existing clinical trial data for T-cell therapy in the SOT context.
  • To discuss manufacturing aspects and regulatory compliance for T-cell products.

Main Methods:

  • Literature review of current T-cell therapy research.
  • Analysis of clinical trial data in SOT and relevant hematopoietic stem cell transplantation (HSCT) studies.
  • Examination of manufacturing processes and Good Manufacturing Practice (GMP) standards.

Main Results:

  • T-cell therapy shows promise for treating viral diseases post-SOT.
  • Clinical trial data, though limited, supports the investigation of T-cell therapies.
  • Manufacturing approaches and GMP compliance are crucial for product efficacy and safety.

Conclusions:

  • T-cell therapy is an emerging and important therapeutic strategy for viral infections after SOT.
  • Further research and standardized manufacturing are needed to optimize T-cell therapy in transplantation.
  • This review highlights the potential of T-cell therapy to improve outcomes for SOT patients with viral complications.