Related Experiment Video
Updated: Apr 5, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
Published on: February 17, 2023
Sleeping Pill Administration Time and Patient Subjective Satisfaction
Seockhoon Chung1, Soyoung Youn1, Kikyoung Yi1
1Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Timing of hypnotic agent administration impacts patient satisfaction. Taking sleeping pills later, with a shorter interval to waking, improves subjective satisfaction with sleep medications.
Area of Science:
- Pharmacology
- Sleep Medicine
- Patient Satisfaction
Background:
- Standard hypnotic agent administration is 30 minutes before bedtime.
- Patient dissatisfaction with sleeping pills is common.
- The influence of administration timing on satisfaction is not well understood.
Purpose of the Study:
- To investigate the relationship between the timing of hypnotic agent administration and patient subjective satisfaction.
- To determine if administration timing influences patient satisfaction with sleeping pills.
Main Methods:
- 112 primary insomnia patients using benzodiazepine or nonbenzodiazepine gamma-aminobutyric acid (GABA) agonists were studied.
- Data collected included administration time, bedtime, sleep onset, and wake-up times.
- Patients were categorized into satisfied and dissatisfied groups based on subjective reports.
Main Results:
- Satisfied patients took hypnotic agents and went to bed later.
- The duration from administration to sleep onset and wake-up was significantly shorter in satisfied patients.
- Short durations from administration to sleep onset and wake-up predicted patient satisfaction.
Conclusions:
- Later administration of hypnotic agents and shorter pre-wake intervals may enhance patient satisfaction.
- Physicians may consider advising patients to take sleeping pills approximately 7 hours before their usual wake-up time.
- This contrasts with the current standard of 30 minutes before bedtime.
More Related Videos
Related Concept Videos
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Sedatives and Hypnotics: Overview
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
Management of Insomnia
Sedatives and Hypnotics Drugs: Benzodiazepines
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
CNS Depressants: Barbiturates and Benzodiazepines
Blind Procedures

