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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Non-Canonical Wnt Signaling Pathways01:41

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Related Experiment Video

Updated: Apr 5, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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Wnt Signaling and Its Contribution to Craniofacial Tissue Homeostasis.

X Yin1, J Li1, B Salmon2

  • 1State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA.

Journal of Dental Research
|August 20, 2015
PubMed
Summary

Activating the Wnt signaling pathway can regenerate damaged dental tissues by awakening dormant stem cells. This discovery holds promise for advancing dental medicine and promoting tissue repair.

Keywords:
dental cementummouth mucosaperiodontal ligamentregenerationstem cellstooth

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Area of Science:

  • Dental Medicine
  • Regenerative Biology
  • Stem Cell Research

Background:

  • Mammalian tissue regeneration is limited compared to lower vertebrates.
  • Regenerative pathways in mammals may be reactivated by specific molecular signals.
  • The Wnt signaling pathway is crucial for stem cell self-renewal and tissue regeneration.

Purpose of the Study:

  • To investigate the role of Wnt signaling in craniofacial tissue regeneration.
  • To map Wnt responsiveness in dental and craniofacial stem/progenitor cells.
  • To highlight the therapeutic potential of Wnt-based strategies for dental healing.

Main Methods:

  • Utilized Wnt reporter and lineage-tracing mouse models.
  • Created molecular maps of Wnt signaling in craniofacial tissues.
  • Analyzed Wnt pathway colocalization with stem/progenitor populations.

Main Results:

  • Wnt signaling patterns were identified in key craniofacial structures, including the incisor apex, dental pulp, alveolar bone, periodontal ligament, cementum, and oral mucosa.
  • These Wnt signaling patterns directly correlated with the location of stem and progenitor cells.
  • Wnt signaling is vital for maintaining and healing these tissues.

Conclusions:

  • Wnt signaling is a critical pathway for craniofacial tissue maintenance and repair.
  • Targeting Wnt signaling offers a promising therapeutic strategy for activating endogenous stem cells to promote dental tissue regeneration.
  • This research opens new avenues for regenerative dental medicine.