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Proadrenomedullin and copeptin in pediatric pneumonia: a prospective diagnostic accuracy study

Gabriel Alcoba1,2, Sergio Manzano3, Laurence Lacroix4

  • 1Pediatric Emergency Division, Geneva University Hospitals (HUG), Rue Gabrielle Perret-Gentil 6, 1211, Geneva 14, Switzerland. gabriel.alcoba@hcuge.ch.

BMC Infectious Diseases
|August 20, 2015
PubMed

Insights

Proadrenomedullin effectively predicts severe pediatric pneumonia and bacteremia, aiding clinical decisions. Copeptin showed no significant predictive value in this study.

Area of Science:

  • Pediatric Infectious Diseases
  • Biomarker Research
  • Critical Care Medicine

Background:

  • Community-acquired pneumonia (CAP) is a major global child mortality cause.
  • Limited research exists on Proadrenomedullin and Copeptin in severe pediatric pneumonia and bacteremia.

Purpose of the Study:

  • To evaluate Proadrenomedullin and Copeptin as predictors of complicated CAP in children.
  • To assess their role in identifying bacteremia and empyema.

Main Methods:

  • 88 children (0-16 years) with pneumonia were studied.
  • Proadrenomedullin and Copeptin levels were measured using B.R.A.H.M.S. Kryptor Compact and TRACE technology.
  • STARD reporting standards were followed.

Main Results:

  • 12.5% of children had complicated CAP.
  • Proadrenomedullin levels were significantly higher in complicated (0.18 vs. 0.08 nmol/L) and bacteremic (0.40 vs. 0.08 nmol/L) pneumonia.
  • Proadrenomedullin > 0.16 nmol/L demonstrated 100% sensitivity for bacteremia.
  • Copeptin provided no additional predictive value.

Conclusions:

  • Proadrenomedullin is a reliable predictor for complicated CAP in children.
  • It may assist in hospitalization decisions and antibiotic route selection.
  • Further large-scale studies are recommended.
Abstract

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