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Updated: Apr 5, 2026

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
Published on: August 1, 2018
Electron Transfer Mechanism in Helical Peptides
Himadri Shekhar Mandal1, Heinz-Bernhard Kraatz1
1Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada.
Abstract:
Electrochemical studies of a set of ferrocene-labeled helical peptides of increasing length were carried out by forming self-assembled monolayers (SAMs) on gold electrodes. Electron transfer (ET) rates showed a very weakly distance dependent nature that has been interpreted as a result of a dynamically controlled tunneling mechanism. Specifically, the slow equilibrium between the α- and the 310 helical conformers in a SAM has been invoked, and the rate of formation of the more conductive 310 conformer has been proposed to be related to the ET rates observed.
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