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The association of the platelet-to-lymphocyte ratio with mitral annular calcification

Çağri Yayla1, Mehmet Kadri Akboga1, Ugur Canpolat1

  • 1a Türkiye Yüksek Ihtisas Training and Research Hospital, Cardiology Clinic , Ankara , Turkey.

Scandinavian Cardiovascular Journal : SCJ
|August 20, 2015
PubMed

Insights

The platelet-to-lymphocyte ratio (PLR) is elevated in patients with mitral annular calcification (MAC). Higher PLR levels are independently associated with the presence of MAC, suggesting its potential as a biomarker.

Area of Science:

  • Cardiology
  • Hematology
  • Biomarkers

Background:

  • Mitral annular calcification (MAC) shares risk factors and pathogenesis with atherosclerosis.
  • Increased platelet-to-lymphocyte ratio (PLR) is linked to atherosclerotic diseases.

Purpose of the Study:

  • To investigate the association between PLR levels and the presence of MAC.
  • To determine if PLR can serve as a biomarker for MAC.

Main Methods:

  • A cohort of 1060 patients (704 with MAC, 356 without) was analyzed.
  • Demographic, clinical, and laboratory data, including complete blood count for PLR calculation, were collected.
  • Statistical analysis identified independent predictors of MAC.

Main Results:

  • Patients with MAC were older and had higher rates of hypertension.
  • Mean PLR was significantly higher in the MAC-positive group (129.1 vs 103.5, p < 0.001).
  • PLR, along with age, hypertension, and NLR, was independently associated with MAC presence (OR: 1.109).

Conclusions:

  • PLR is significantly increased in patients with MAC.
  • PLR is an independent predictor of MAC presence.
  • Elevated PLR may indicate an increased risk or presence of MAC.
Abstract

Keywords:
inflammationmitral annular calcificationplatelet-to-lymphocyte ratio

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