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Related Experiment Video

Updated: Apr 5, 2026

Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity
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Aspheric versus wavefront-guided photorefractive keratectomy: contralateral eye study.

Siamak Zarei-Ghanavati1, Hamid Gharaee1, David Rex Hamilton1

  • 1From the Cornea Research Center (Zarei-Ghanavati, Gharaee), Mashhad University of Medical Sciences, Mashhad, and the Eye Research Center (Abrishami), Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran; the Laser Refractive Center (Hamilton, Sanchez), Jules Stein Eye Institute, School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

Journal of Cataract and Refractive Surgery
|August 20, 2015
PubMed
Summary

Both wavefront-guided and aspheric photorefractive keratectomy (PRK) offer similar visual and refractive outcomes. Aspheric PRK resulted in fewer higher-order aberrations (HOAs) compared to wavefront-guided PRK after myopic correction.

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Area of Science:

  • Ophthalmology
  • Refractive Surgery
  • Corneal Surgery

Background:

  • Photorefractive keratectomy (PRK) is a common refractive surgery for myopia.
  • Wavefront-guided (WFG) and aspheric ablation profiles aim to optimize visual outcomes.
  • Comparing these advanced PRK techniques is crucial for patient selection and surgical planning.

Purpose of the Study:

  • To compare refractive, visual, and aberrometric outcomes of wavefront-guided PRK versus aspheric PRK in myopic patients.
  • To evaluate the efficacy and safety of two distinct PRK ablation profiles.
  • To assess the impact of PRK on higher-order aberrations (HOAs).

Main Methods:

  • A prospective randomized clinical trial was conducted involving 48 myopic patients (96 eyes).
  • One eye per patient underwent WFG-PRK (Zyoptix), and the other eye underwent aspheric PRK (Technolas 217z).
  • Preoperative and 3- and 6-month postoperative outcomes including visual acuity, contrast sensitivity, and HOAs were analyzed.

Main Results:

  • No significant differences were found in uncorrected or corrected distance visual acuity (UDVA/CDVA) between the two groups.
  • Both methods equally improved contrast sensitivity, with no between-group differences.
  • While HOAs increased post-PRK in both groups, aspheric PRK induced statistically fewer HOAs (P = .04).

Conclusions:

  • Both wavefront-guided and aspheric PRK provide comparable visual and refractive results.
  • Aspheric PRK demonstrates an advantage in inducing fewer higher-order aberrations compared to wavefront-guided PRK.
  • Both techniques effectively improve contrast sensitivity in myopic patients.