Bilateral Systematized Epidermolytic Verrucous Epidermal Nevus: A Rare Entity

Area of Science:

• Dermatology
• Histopathology
• Genetics

Background:

• Verrucous epidermal nevi are congenital hamartomas of keratinocytes.
• They typically follow Blaschko lines and exhibit hyperkeratosis without atypia.
• Histological findings include hyperkeratosis, acanthosis, papillomatosis, and occasionally epidermolytic hyperkeratosis.

Purpose of the Study:

• To report a rare case of systematized verrucous epidermal nevi.
• To describe the clinical and histopathological features of this rare entity.

Main Methods:

• Case study of a 3-year-old boy.
• Clinical examination of skin lesions.
• Histopathological analysis of skin biopsy.

Main Results:

• The patient presented with bilaterally symmetrical, verrucous plaques along Blaschko lines on the trunk and extremities.
• Facial and palmoplantar skin were spared.
• Histopathology confirmed epidermal nevi with prominent epidermolytic hyperkeratosis.

Conclusions:

• This case highlights the rare presentation of systematized verrucous epidermal nevi.
• The prominent epidermolytic hyperkeratosis is a notable histopathological finding in this rare congenital condition.