Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Disorders of the Autonomic Nervous System

Disorders of the Autonomic Nervous System

The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...

Accessory Structures of the Skin: Sweat Glands

Accessory Structures of the Skin: Sweat Glands

Sweat glands or sudoriferous glands are one of the important accessory structures of the skin. They are small, coiled tubular structures located in the dermis, the middle layer of the skin. Sweat glands are responsible for producing and secreting sweat, a watery fluid that helps regulate body temperature and excrete waste products.
Sweat glands are classified as merocrine glands; that is, the secretions are excreted by exocytosis through a duct without affecting the cells of the gland. There...

Myasthenia Gravis: Overview and Treatment

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...

Generalized Anxiety Disorder

Generalized Anxiety Disorder

Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...

Adrenal Gland Disorders

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...

Immunodeficiency Diseases

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Disseminated Molluscum Contagiosum Treated with Cidofovir in a 16 Year Old with Acute Lymphoblastic Leukemia.

Indian dermatology online journal·2025

Same author

When the Skin Speaks: Dermatological Clues in Multiple Myeloma.

Indian dermatology online journal·2025

Same author

Can Lichen Planus be a Forerunner of Paraneoplastic Pemphigus?

Indian journal of dermatology·2024

Same author

A man having 'cyst' in the 'cyst'!

Respirology case reports·2024

Same author

Authors' reply.

Indian journal of dermatology, venereology and leprology·2023

Same author

A Case of Desmoplastic Trichoepithelioma with a New Dermoscopy Finding.

Indian journal of dermatology·2023

Search research articles

Related Experiment Video

Updated: Apr 5, 2026

Quantitative Autonomic Testing

Quantitative Autonomic Testing

Published on: July 19, 2011

Acquired Idiopathic Generalized Anhidrosis.

Geethu Gangadharan¹, Sebastian Criton¹, Divya Surendran²

¹Department of Dermatology, Amala Institute of Medical Sciences, Amala Nagar, Thrissur, Kerala, India.

Indian Journal of Dermatology

|August 20, 2015

Summary

Acquired idiopathic generalized anhidrosis is a rare condition with unknown causes. A new case suggests an autoimmune process targeting sweat glands may be responsible, potentially linking it to lichen planus development.

Keywords:

Acquired idiopathic generalized anhidrosis anhidrosis lichen planus

More Related Videos

A Detailed Protocol for Perspiration Monitoring Using a Novel, Small, Wireless Device

A Detailed Protocol for Perspiration Monitoring Using a Novel, Small, Wireless Device

Published on: November 24, 2016

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

Related Experiment Videos

Last Updated: Apr 5, 2026

Quantitative Autonomic Testing

Quantitative Autonomic Testing

Published on: July 19, 2011

A Detailed Protocol for Perspiration Monitoring Using a Novel, Small, Wireless Device

A Detailed Protocol for Perspiration Monitoring Using a Novel, Small, Wireless Device

Published on: November 24, 2016

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

Area of Science:

Dermatology
Immunology
Pathophysiology

Background:

Acquired idiopathic generalized anhidrosis (AIGA) is a rare disorder characterized by the inability to sweat.
The underlying pathomechanism of AIGA remains largely unknown.
Autoimmune conditions can affect various skin structures, including sweat glands.

Purpose of the Study:

To describe a unique case of AIGA.
To investigate a potential pathomechanism for AIGA.
To explore the association between AIGA and lichen planus.

Main Methods:

Case report of a patient with AIGA.
Clinical observation of disease progression.
Review of potential autoimmune etiologies.

Main Results:

The patient presented with acquired idiopathic generalized anhidrosis.
The patient subsequently developed lichen planus.
This temporal association suggests a possible autoimmune-mediated mechanism.

Conclusions:

An autoimmune process targeting sweat glands is a probable pathomechanism for AIGA.
The development of lichen planus may be linked to this autoimmune destruction.
Further research is warranted to confirm the autoimmune etiology of AIGA.