Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.5K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.5K
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

807
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
807
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

921
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
921
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

894
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
894
Diphtheria01:28

Diphtheria

93
Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
93
Flail Chest-I01:24

Flail Chest-I

1.0K
Overview of Flail Chest
Flail chest is a severe and potentially life-threatening condition characterized by the fracture of three or more adjacent ribs in multiple places. It is most commonly caused by direct impacts and trauma, such as motor vehicle accidents or injuries from a steering wheel impact. It can also occur due to falls in elderly individuals with osteoporosis, or assaults involving sharp objects.
Pathophysiology
The pathophysiology of flail chest is complex, involving fractures of...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

NEMESIS: Noninferiority, Individual-Patient Metaanalysis of Selective Internal Radiation Therapy with <sup>90</sup>Y Resin Microspheres Versus Sorafenib in Advanced Hepatocellular Carcinoma.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2020
Same author

COVID-19: Don't Neglect the Gastrointestinal Tract!

Digestive diseases (Basel, Switzerland)·2020
Same author

Helicobacter pylori "Test-and-Treat" strategy with urea breath test: A cost-effective strategy for the management of dyspepsia and the prevention of ulcer and gastric cancer in Spain-Results of the Hp-Breath initiative.

Helicobacter·2020
Same author

Gastric cancer in autoimmune gastritis: A case-control study from the German centers of the staR project on gastric cancer research.

United European gastroenterology journal·2020
Same author

Correlation of skin rash and overall survival in patients with pancreatic cancer treated with gemcitabine and erlotinib - results from a non-interventional multi-center study.

BMC cancer·2020
Same author

"My Friend with HIV Remains a Friend": HIV/AIDS Stigma Reduction through Education in Secondary Schools-A Pilot Project in Buea, Cameroon.

Journal of the International Association of Providers of AIDS Care·2020
Same journal

Laparoscopic Pylorus- and Spleen-Preserving Duodenopancreatectomy for a Multifocal Neuroendocrine Tumor.

Viszeralmedizin·2016
Same journal

Palliative Endoscopic Therapy of Esophageal Cancer.

Viszeralmedizin·2016
Same journal

Definitive, Preoperative, and Palliative Radiation Therapy of Esophageal Cancer.

Viszeralmedizin·2016
Same journal

Perioperative and Palliative Chemotherapy for Esophageal Cancer.

Viszeralmedizin·2016
Same journal

Evidence-Based Operative Details in Esophageal Cancer Treatment: Surgical Approach, Lymphadenectomy, Anastomosis.

Viszeralmedizin·2016
Same journal

Minimally Invasive Techniques and Hybrid Operations for Esophageal Cancer.

Viszeralmedizin·2016
See all related articles

Related Experiment Video

Updated: Apr 5, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

1.5K

Whipple's Disease.

Wilfried Obst1, Ulrike von Arnim1, Peter Malfertheiner1

  • 1Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University of Magdeburg, Germany.

Viszeralmedizin
|August 20, 2015
PubMed
Summary
This summary is machine-generated.

Whipple's disease, a rare cause of malabsorption, stems from Tropheryma whipplei infection. Early non-specific symptoms delay diagnosis, but modern methods improve treatment outcomes for this chronic condition.

Keywords:
Malabsorption syndromeTropheryma whippleiWhipple's disease

More Related Videos

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

25.1K
Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
09:44

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

596

Related Experiment Videos

Last Updated: Apr 5, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

1.5K
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

25.1K
Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
09:44

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

596

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Immunology

Background:

  • Whipple's disease (WD) is a rare chronic intestinal infection caused by Tropheryma whipplei, leading to malabsorption and lymphostasis.
  • Low incidence and non-specific early symptoms often result in delayed diagnosis, sometimes after many years.

Purpose of the Study:

  • To review current knowledge on Whipple's disease, covering pathogenesis, clinical presentation, diagnosis, and therapy.
  • To highlight recent advancements in diagnostic and therapeutic approaches for WD.

Main Methods:

  • Selective literature review and clinical experience of the authors.
  • Analysis of pathogenesis, clinical manifestations, diagnostic techniques (PAS staining, immunohistochemistry, PCR), and treatment protocols.

Main Results:

  • WD pathogenesis involves host-specific intestinal macrophage dysfunction.
  • Early symptoms are non-specific (polyarthralgia, fever, fatigue), preceding malabsorption.
  • Diagnostic methods include PAS-positive macrophages, immunohistochemistry, PCR, and endoscopic findings (edema, lymphangiectasias).
  • Treatment involves intravenous ceftriaxone followed by oral trimethoprim/sulfamethoxazole.

Conclusions:

  • Whipple's disease is a rare but potentially lethal cause of malabsorption if unrecognized.
  • Advanced diagnostic tools and approved therapies enable adequate patient management.
  • Lifelong follow-up is essential due to host-specific susceptibility to T. whipplei.