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Genotype 4 Hepatitis E Virus Prevalent in Eastern China Shows Diverse Subtypes
Hua Tian1, Xingli Fu2, Wang Li2
1Jiangsu Provincial Center for Disease Prevention and Control, Nanjing, China.
Hepatitis Monthly
|August 20, 2015
Summary
Hepatitis E Virus (HEV) genotype 4 in China shows diverse subtypes, with some strains found in both humans and swine, indicating cross-species transmission. This study investigated HEV subtypes in eastern China.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Hepatitis E Virus (HEV) is a zoonotic pathogen with various animal reservoirs, notably swine, which are a major source of human infection.
- Genotype 4 HEV is the predominant cause of hepatitis E in China.
- Limited research exists on HEV subtypes in eastern China.
Purpose of the Study:
- To investigate the prevalent subtypes of Hepatitis E Virus (HEV) in eastern China.
- To analyze the genetic diversity of HEV genotype 4 in human and swine populations.
Main Methods:
- Screening of 125 human serum and 290 swine fecal samples for HEV RNA using reverse transcription polymerase chain reaction (RT-PCR).
- Sequencing of positive PCR products.
- Phylogenetic analysis of HEV strains based on the partial capsid gene.
Main Results:
- HEV RNA was detected in 19.2% of human serum samples and 9.66% of swine fecal samples.
- All 51 identified HEV strains belonged to genotype 4.
- Phylogenetic analysis revealed 6 distinct subtypes of HEV genotype 4, with some isolates shared between human and swine populations.
Conclusions:
- Hepatitis E Virus (HEV) genotype 4 in eastern China exhibits significant subtype diversity.
- Evidence suggests cross-species transmission of certain HEV isolates between humans and swine.
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