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Related Experiment Videos

What to do With Wake-Up Stroke.

Mark N Rubin1, Kevin M Barrett2

  • 1Department of Neurology, Divisions of Hospital & Vascular Neurology, Mayo Clinic, Scottsdale, AZ, USA.

The Neurohospitalist
|August 20, 2015
PubMed
Summary
This summary is machine-generated.

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Wake-up strokes, occurring in 1 in 5 ischemic stroke cases, present a treatment challenge. Advanced neuroimaging may help identify patients eligible for reperfusion therapy, improving outcomes.

Area of Science:

  • Neurology
  • Radiology
  • Emergency Medicine

Background:

  • Wake-up stroke, where symptoms appear after sleep, constitutes approximately 20% of acute ischemic strokes.
  • These patients are often excluded from clinical trials and reperfusion therapy, leading to worse prognoses.
  • Current neuroimaging techniques show potential for identifying treatment windows.

Purpose of the Study:

  • To explore the utility of advanced neuroimaging in managing wake-up strokes.
  • To assess the potential for reperfusion therapy in wake-up stroke patients based on imaging findings.

Main Methods:

  • Review of neuroimaging studies including noncontrast CT, MRI, and perfusion-based CT/MRI.
  • Analysis of pilot studies and ongoing randomized trials for wake-up stroke treatment.
Keywords:
acute strokehemorrhageoutcometPAthrombolysiswake-up stroke

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Main Results:

  • Neuroimaging suggests wake-up strokes may occur just before awakening.
  • Imaging may aid in selecting wake-up stroke patients for acute reperfusion therapy.
  • Pilot studies show promise, but generalizability is limited.

Conclusions:

  • Neuroimaging is crucial for understanding wake-up stroke timing and patient selection.
  • Further research and ongoing trials are needed to establish reperfusion therapy benefits.
  • Identifying a treatable subset of wake-up stroke patients is a key goal.