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Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
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Structural Insights Lead to a Negamycin Analogue with Improved Antimicrobial Activity against Gram-Negative Pathogens

David C McKinney1, Gregory S Basarab1, Alexis I Cocozaki1

  • 1Departments of Chemistry and Bioscience, Infection Innovative Medicines; Structure and Biophysics, Discovery Sciences; Discovery Safety, Drug Safety and Metabolism, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.

ACS Medicinal Chemistry Letters
|August 20, 2015
PubMed

Keywords:
AntibacterialGram-negativenatural productnegamycinribosome

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