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Ocular pseudoexfoliation syndrome and life span
Jon Klokk Slettedal1, Leiv Sandvik2, Amund Ringvold3
1Institute of Clinical Medicine, University of Oslo, Norway ; Department of Ophthalmology, Oslo University Hospital, Oslo, Norway.
Ebiomedicine
|August 20, 2015
Summary
Pseudoexfoliation syndrome (PES) does not impact lifespan. This study found no significant difference in life span for individuals with or without ocular PES, indicating it is not life-threatening.
Area of Science:
- Ophthalmology
- Gerontology
- Epidemiology
Background:
- Pseudoexfoliation syndrome (PES) is an ocular condition associated with systemic manifestations.
- The impact of PES on overall longevity remains incompletely understood.
Purpose of the Study:
- To compare the life span of individuals with and without ocular pseudoexfoliation syndrome (PES).
Main Methods:
- An epidemiological survey in Sør-Trøndelag county, Norway, included 2109 inhabitants over 64 years of age.
- Mortality data were obtained up to 2014, with 99% of participants deceased by this time.
Main Results:
- Life span was not statistically different between individuals with and without PES, after adjusting for age and gender.
- Survival extended up to and beyond 30 years following a PES diagnosis.
Conclusions:
- Systemic pseudoexfoliation syndrome (PES) does not appear to be a life-threatening condition.
- Extraocular organs and tissues show minimal functional changes despite reported systemic aberrations in individuals with ocular PES.
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