Polysaccharide-Based Nanocarriers for Ocular Drug Delivery

Area of Science:

• Pharmaceutical Technology
• Nanomedicine
• Ocular Drug Delivery

Background:

• Achieving effective ocular drug delivery with sustained therapeutic concentrations at target tissues remains a significant challenge in pharmaceutical technology.
• Nanotechnology provides advanced drug carrier systems for enhanced ocular drug delivery.
• Biodegradable polymers, particularly polysaccharides, are key biomaterials for developing safe and effective nanocarriers (NCs).

Purpose of the Study:

• To review recent advancements in polysaccharide-based nanocarriers (NCs) for ocular drug delivery.
• To highlight the potential of these nanocarriers in improving drug concentration and residence time in ocular tissues.
• To discuss the application of polysaccharide NCs in treating various ocular disorders.

Main Methods:

• Review of recent scientific literature on polysaccharide-based nanocarriers for ocular applications.
• Analysis of different types of polysaccharide nanocarriers (matrix vs. coated).
• Focus on studies demonstrating improved drug transport and therapeutic efficacy in ocular tissues.

Main Results:

• Polysaccharide-based nanocarriers (NCs) demonstrate significant potential for improving ocular drug delivery.
• Both polysaccharide-matrix and polysaccharide-coated carriers enhance drug transport to various ocular compartments.
• These nanocarriers can sustain efficient drug concentrations at target tissues for extended periods.

Conclusions:

• Polysaccharide-based nanocarriers represent a promising strategy for advancing ocular drug delivery systems.
• Their biocompatibility and biodegradability make them ideal for developing advanced ocular formulations.
• Further research into polysaccharide NCs can lead to improved treatments for ocular disorders.