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Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review
Joshua Boateng1, Obinna Okeke, Sajjad Khan
1Department of Pharmaceutical, Chemical and Environmental Sciences, Faculty of Engineering and Science, University of Greenwich at Medway, Central Avenue, Chatham Maritime, ME4 4TB, Kent, UK. J.S.Boateng@gre.ac.uk.
Current Pharmaceutical Design
|August 21, 2015
Summary
Novel bioadhesive drug delivery systems using natural polysaccharide polymers offer safe and effective alternatives to traditional methods. These systems enhance drug absorption and local action across various mucosal surfaces for improved patient outcomes.
Area of Science:
- Biomaterials Science
- Pharmaceutics
- Drug Delivery
Background:
- Traditional drug administration routes (parenteral, oral) have limitations like first-pass metabolism and systemic side effects.
- Mucosal drug delivery offers advantages such as avoiding first-pass metabolism and enabling localized drug action.
- Bioadhesive vehicles are crucial for prolonged residence time, enhancing drug absorption and therapeutic efficacy at mucosal sites.
Purpose of the Study:
- To review bioadhesive polymers of polysaccharide origin for mucosal drug delivery.
- To explore various dosage forms and their suitability for different mucosal routes.
- To discuss the challenges and strategies for therapeutic efficacy at mucosal sites.
Main Methods:
- Literature review of polysaccharide-based bioadhesive polymers.
- Analysis of drug delivery systems for ocular, oral, nasal, gastrointestinal, and vaginal mucosa.
- Examination of strategies for optimizing drug absorption and local action.
Main Results:
- Polysaccharide-based polymers demonstrate biocompatibility, biodegradability, and safety for mucosal applications.
- Various dosage forms utilizing these polymers can achieve prolonged residence time and therapeutic benefits.
- Site-specific anatomical and physiological challenges are addressed by tailored delivery strategies.
Conclusions:
- Naturally occurring polysaccharide polymers are promising candidates for developing advanced bioadhesive drug delivery systems.
- These systems offer a safe and effective platform for drug administration via multiple mucosal routes.
- Further research into polysaccharide-based formulations can optimize drug delivery for diverse therapeutic needs.
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