Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Metabolism01:40

Overview of Metabolism

41.1K
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
41.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploiting the polypharmacology of alectinib for synergistic RNA splicing disruption with RBM39 degraders.

Cell reports·2026
Same author

RAS/PI3K pathway mutations sensitise epithelial ovarian cancer cells to a PARP/NAMPT inhibitor combination.

Communications biology·2025
Same author

The exit of naive pluripotency contains a metabolism-induced checkpoint for telomere homeostasis.

Cell reports·2025
Same author

Multi-omics architecture of childhood obesity and metabolic dysfunction uncovers biological pathways and prenatal determinants.

Nature communications·2025
Same author

PTEN Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma.

Cancer research·2024
Same author

Editorial overview: Recent advances in metabolomics.

Current opinion in chemical biology·2024

Related Experiment Video

Updated: Apr 5, 2026

The MPLEx Protocol for Multi-omic Analyses of Soil Samples
10:12

The MPLEx Protocol for Multi-omic Analyses of Soil Samples

Published on: May 30, 2018

11.8K

Metabolic profiling in human exposome studies.

Toby J Athersuch1, Hector C Keun2

  • 1Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College Norfolk Place, London, London W2 1PG, UK toby.athersuch@imperial.ac.uk.

Mutagenesis
|August 21, 2015
PubMed
Summary
This summary is machine-generated.

Metabolic profiling of the human metabolome offers insights into environmental exposures and chronic disease. This approach aids in understanding complex biological systems and advancing environmental health research.

More Related Videos

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
11:02

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

1.4K
Metabolic Analysis of Drosophila melanogaster Larval and Adult Brains
07:06

Metabolic Analysis of Drosophila melanogaster Larval and Adult Brains

Published on: August 7, 2018

10.1K

Related Experiment Videos

Last Updated: Apr 5, 2026

The MPLEx Protocol for Multi-omic Analyses of Soil Samples
10:12

The MPLEx Protocol for Multi-omic Analyses of Soil Samples

Published on: May 30, 2018

11.8K
Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
11:02

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

1.4K
Metabolic Analysis of Drosophila melanogaster Larval and Adult Brains
07:06

Metabolic Analysis of Drosophila melanogaster Larval and Adult Brains

Published on: August 7, 2018

10.1K

Area of Science:

  • Environmental Health Sciences
  • Metabolomics
  • Systems Biology

Background:

  • The human metabolome, comprising small molecules in biofluids and tissues, is a key component of the human exposome.
  • Metabolic profiling (metabolomics) enables detailed characterization of biospecimens, crucial for population studies.
  • Understanding the metabolome is vital for linking environmental factors to chronic diseases.

Purpose of the Study:

  • To discuss the application of metabolic profiling in exposome studies.
  • To highlight the complexity and dynamism of the metabolome.
  • To identify challenges and requirements for real-world phenotyping in environmental health research.

Main Methods:

  • Application of metabolic profiling techniques to human biospecimens.
  • Analysis of population studies to uncover environmental factor-disease associations.
  • Systems-level interpretation of biological phenomena using metabolic phenotypes.

Main Results:

  • Metabolic profiling provides valuable insights into the exposome and its relation to health.
  • Metabolic phenotypes anchor other molecular data for a holistic biological interpretation.
  • Recent exemplars demonstrate the utility of metabolic profiling in exposome research.

Conclusions:

  • Metabolic profiling is a powerful tool for exposome research and environmental health.
  • Addressing the complexity and dynamism of the metabolome is essential for successful phenotyping.
  • Future challenges in large-scale exposome studies require strategic approaches to maximize utility.