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Disseminated Herpes Simplex Virus with Fulminant Hepatitis
Bassam H Rimawi1, Joseph Meserve2, Ramzy H Rimawi3
1Division of Maternal Fetal Medicine and Reproductive Infectious Diseases, Department of Gynecology and Obstetrics, Emory University School of Medicine, 550 Peachtree Street, 8th Floor, Atlanta, GA 30303, USA.
Case Reports in Hepatology
|August 21, 2015
Summary
Disseminated herpes simplex virus (HSV) can cause severe liver failure. Prompt acyclovir treatment is crucial for survival in patients with necrotizing hepatitis.
Area of Science:
- Hepatology
- Virology
- Infectious Diseases
Background:
- Disseminated herpes simplex virus (HSV) is a rare but serious condition.
- It can lead to acute fulminant liver failure and necrotizing hepatitis.
Purpose of the Study:
- To present a case series of patients with disseminated HSV and acute liver failure.
- To highlight the efficacy of acyclovir in treating this condition.
Main Methods:
- Case series of three patients.
- Treatment with a one-week course of acyclovir.
- Monitoring for clinical improvement and viral clearance.
Main Results:
- All three patients with acute disseminated HSV and necrotizing hepatitis showed successful recovery.
- Acyclovir therapy was effective in treating the condition.
Conclusions:
- Early empiric administration of acyclovir is critical for managing potentially lethal disseminated HSV infection.
- Prompt treatment can prevent severe liver damage and improve patient outcomes.
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