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Reference Equation for Respiratory Pressures in Pediatric Population: A Multicenter Study.

Fernanda Cordoba Lanza1, Mara Lisiane de Moraes Santos2, Jessyca Pachi Rodrigues Selman3

  • 1Postgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho - UNINOVE, Sao Paulo, SP, Brazil.

Plos One
|August 21, 2015
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Summary

This study developed new prediction equations for respiratory muscle strength in children and teenagers, accounting for age and sex. These multicenter-derived equations improve accuracy for maximal inspiratory pressure (PImax) and maximal expiratory pressure (PEmax) assessments.

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Area of Science:

  • Pediatric Pulmonology
  • Respiratory Physiology
  • Clinical Biomechanics

Background:

  • Existing respiratory muscle strength prediction equations lack age-specific pediatric data.
  • Previous research was limited by single-center designs, potentially affecting generalizability.

Purpose of the Study:

  • To establish multicenter-derived reference equations for maximal inspiratory pressure (PImax) and maximal expiratory pressure (PEmax) in healthy children and teenagers.
  • To address limitations of previous single-center studies and single prediction equations.

Main Methods:

  • A multicenter study involving 450 healthy volunteers aged 6-18 years with normal lung function.
  • Exclusion criteria included high physical activity, prematurity, smoking, and chronic diseases.
  • Volunteers were divided into two age groups (6-11 and 12-18 years) for PImax and PEmax measurements.

Main Results:

  • Developed distinct prediction equations for PImax and PEmax for two age groups (6-11 and 12-18 years).
  • Equations incorporate age, sex, and Body Mass Index (BMI) for improved predictive accuracy.
  • Reported mean PImax of 85.6 cmH2O and PEmax of 84.6 cmH2O in the study population.

Conclusions:

  • This multicenter study provides validated prediction equations for respiratory muscle strength in pediatric populations.
  • The new equations offer a more accurate assessment of PImax and PEmax compared to previous models.
  • These findings are crucial for clinical evaluation and research involving respiratory function in children and adolescents.