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Pleuropulmonary Meningothelial Proliferations: Evidence for a Common Histogenesis

Annikka Weissferdt1, Ximing Tang, Saul Suster

  • 1Departments of *Pathology †Translational Molecular Pathology, MD Anderson Cancer Center, Houston, TX ‡Department of Pathology, Medical College of Wisconsin, Milwaukee, WI.

The American Journal of Surgical Pathology
|August 21, 2015
PubMed

Insights

Minute pulmonary meningothelial-like nodules (MPMN) and pleural or pulmonary meningiomas (PPM) share genetic similarities with central nervous system (CNS) meningiomas. These pleuropulmonary lesions also exhibit NF2 gene alterations, suggesting common origins and potential therapeutic targets.

Area of Science:

  • Oncology
  • Genetics
  • Pathology

Background:

  • Primary pleuropulmonary meningothelial proliferations, including minute pulmonary meningothelial-like nodules (MPMN) and pleural or pulmonary meningiomas (PPM), resemble central nervous system (CNS) meningiomas histologically.
  • CNS meningiomas frequently harbor genetic abnormalities, particularly involving the neurofibromatosis type 2 (NF2) gene on chromosome 22.
  • The molecular basis of pleuropulmonary meningothelial lesions remains largely unexplored.

Purpose of the Study:

  • To investigate the status of the NF2 gene in pleuropulmonary meningothelial proliferations.
  • To compare the genetic alterations in these lesions with those found in CNS meningiomas.
  • To explore potential common molecular pathways and precursor cells for these related tumors.

Main Methods:

  • Analysis of whole tissue sections from 9 pleuropulmonary meningothelial lesions (6 MPMNs, 3 PPMs) and 9 CNS meningiomas.
  • Utilized interphase fluorescence in situ hybridization (FISH) with a locus-specific probe for the NF2 gene region on chromosome 22.

Main Results:

  • NF2 gene deletion was detected in 2 MPMNs, 1 PPM, and 4 CNS meningiomas.
  • Chromosomal gains at 22q were observed in 2 MPMNs and 1 PPM.
  • These findings indicate shared genetic alterations between pleuropulmonary and CNS meningiomas.

Conclusions:

  • Pleuropulmonary meningothelial lesions share common genetic pathways with CNS meningiomas.
  • The results support the hypothesis that MPMN and PPM may originate from the same precursor cell.
  • Identified genetic changes may offer targets for future personalized therapies in pleuropulmonary meningiomas.

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