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Vitamin E function and requirements in relation to PUFA.

Daniel Raederstorff1, Adrian Wyss1, Philip C Calder2

  • 11DSM Nutritional Products,Basel CH-4002,Switzerland.

The British Journal of Nutrition
|August 21, 2015
PubMed
Summary
This summary is machine-generated.

Vitamin E (α-tocopherol) is crucial for protecting cells from damage. Higher intake of polyunsaturated fatty acids (PUFA) necessitates increased vitamin E intake to maintain adequate antioxidant protection.

Keywords:
α-TocopherolIoM Institute of MedicinePUFARecommendationsRequirementsVitamin E

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Area of Science:

  • Nutritional Biochemistry
  • Antioxidant Research

Background:

  • Vitamin E (α-tocopherol) functions as a vital lipophilic antioxidant in humans.
  • It protects lipoproteins, polyunsaturated fatty acids (PUFA), and cell membranes from oxidative damage.

Purpose of the Study:

  • To review and evaluate published data on vitamin E requirements.
  • To assess the relationship between vitamin E needs and dietary PUFA intake.

Main Methods:

  • Systematic review of existing animal and human studies.
  • Analysis of data correlating PUFA consumption with vitamin E requirements.

Main Results:

  • A basal vitamin E requirement of 4-5 mg/d RRR-α-tocopherol is indicated with very low PUFA diets.
  • Vitamin E needs increase with higher PUFA intake and greater fatty acid unsaturation.
  • Calculated requirements range from 0.4-0.6 mg RRR-α-tocopherol/g linoleic acid and 12-20 mg/d for typical PUFA intakes.

Conclusions:

  • Increased PUFA consumption, recommended for health benefits, requires a corresponding increase in vitamin E intake.
  • Many populations already have insufficient vitamin E intake, highlighting the need for adequate supplementation with increased PUFA.
  • Ensuring sufficient vitamin E is prudent to counterbalance the pro-oxidant potential of higher PUFA diets.