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Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
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Immunization of preterm infants

Arnaud Gagneur1, Didier Pinquier2, Caroline Quach3

  • 1a Department of Pediatrics ; Faculty of Medicine and Health Sciences, University of Sherbrooke ; Sherbrooke , Québec , Canada.

Human Vaccines & Immunotherapeutics
|August 21, 2015
PubMed

Insights

Preterm infants benefit from early vaccination schedules, similar to full-term infants, to protect against vaccine-preventable diseases. Special attention to the hepatitis B vaccine is needed for low-birth-weight infants.

Area of Science:

  • Pediatrics
  • Immunology
  • Vaccinology

Background:

  • Premature infants face higher risks of vaccine-preventable diseases.
  • Vaccinations are often delayed in preterm infants, despite their vulnerability.

Purpose of the Study:

  • To review current knowledge on vaccine response, protection, safety, and tolerability in preterm infants.
  • To provide evidence-based recommendations for vaccinating preterm infants.

Main Methods:

  • Review of available data on immune response to vaccines in preterm infants.
  • Analysis of protection derived from routine immunization in this population.
  • Evaluation of vaccine safety and tolerability in preterm infants.

Main Results:

  • Early immunization without correcting for gestational age is supported by available data.
  • While initial antibody response may be lower, protective levels and memory are often achieved.
  • Vaccines are immunogenic, safe, and well-tolerated in preterm infants.

Conclusions:

  • Preterm infants should follow standard vaccination schedules, except for hepatitis B vaccine.
  • Additional hepatitis B vaccine doses are recommended for low-birth-weight infants (<2000g) due to reduced immune response.

Keywords:
immunizationneonatepretermvaccines

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