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Integrated Compensatory Responses in a Human Model of Hemorrhage
Published on: November 20, 2016
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[COMPREHENSIVE ASSESSMENT OF THE HEMOSTASIS SYSTEM IN TEST-SUBJECTS IN EXPERIMENT "MARS-500"]
Aviakosmicheskaia I Ekologicheskaia Meditsina = Aerospace and Environmental Medicine
|August 22, 2015
Summary
Long-term isolation in a sealed chamber altered blood clotting. Hemostasis studies revealed slower intrinsic pathway coagulation and increased activity of antithrombin III and protein C-inhibited factors.
Area of Science:
- Physiology
- Hematology
- Environmental Medicine
Context:
- Understanding human physiological adaptation to extreme environments is crucial.
- Long-duration confinement studies, like those in airtight chambers, simulate conditions relevant to spaceflight and isolated habitats.
- Hemostasis, the process of blood clotting, is sensitive to physiological changes.
Purpose:
- To investigate the hemostasis system's response during prolonged confinement in an airtight chamber (520 days).
- To analyze changes in key coagulation and fibrinolysis parameters.
- To identify trends in plasma concentrations and factor activities.
Summary:
- Hemostasis parameters were monitored over 520 days of isolation.
- Significant findings include altered plasma fibrinogen concentration and slower blood coagulation via the intrinsic pathway and final stages.
- A relative increase in the activity of antithrombin III (ATIII) and protein C (PC)-inhibited factors was observed, while other parameters showed varied trends.
Impact:
- Provides insights into the hemostatic system's resilience and adaptability under prolonged isolation stress.
- Highlights potential thrombotic or bleeding risks associated with long-term confinement.
- Informs countermeasures for maintaining hemostatic balance in isolated and confined environments.
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