Therapeutic advances in tremor.

Area of Science:

• Neurology
• Movement Disorders
• Neuroscience

Background:

• Tremor is a prevalent movement disorder with limited progress due to poor understanding of underlying causes.
• Effective treatments for various tremor types remain a significant clinical challenge.

Purpose of the Study:

• To review recent treatment innovations for tremor conditions since 2013.
• To highlight advancements in both invasive and non-invasive therapeutic approaches.

Main Methods:

• Literature review of studies published since 2013 focusing on tremor treatments.
• Summary of clinical trial outcomes for essential tremor, parkinsonian tremor, multiple sclerosis tremor, and functional tremor.
• Inclusion of novel neurostimulation techniques and neuroprosthetic devices.

Main Results:

• Essential tremor shows promise with Octanol studies, refined deep brain stimulation, and MRI-guided focused ultrasound.
• Investigational therapies for essential and parkinsonian tremor include electrical and magnetic stimulation.
• Multiple sclerosis tremor has shown positive open-label results with certain medications, but cannabinoid trials were negative.
• Functional tremor responded positively to retraining, and neuroprosthetics were tested across various tremor types.

Conclusions:

• Several promising medical and surgical treatment trials for tremor are ongoing.
• Continued research into novel therapies offers hope for improved management of movement disorders like tremor.