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Bedaquiline and delamanid in tuberculosis
Susanna Esposito1, Sonia Bianchini1, Francesco Blasi2
1a 1 Università degli Studi di Milano, Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico , Milan, Italy +39 02 55 03 24 98 ; +39 02 50 32 02 06 ; susanna.esposito@unimi.it.
Expert Opinion on Pharmacotherapy
|August 22, 2015
Summary
New drugs bedaquiline and delamanid show promise for treating drug-resistant tuberculosis (TB). While effective in adults, further pediatric studies are needed to assess safety and drug interactions.
Area of Science:
- Pharmacology and Infectious Diseases
- Tuberculosis Treatment and Drug Development
Background:
- Rising emergence of drug-resistant tuberculosis (TB) necessitates novel therapeutic agents.
- Factors contributing to resistance include poor adherence, drug quality, and treatment errors.
Purpose of the Study:
- To review the characteristics and role of bedaquiline and delamanid in managing resistant TB.
- To evaluate the efficacy and safety profiles of these new anti-TB drugs.
Main Methods:
- Review of existing literature on bedaquiline and delamanid.
- Summary of pharmacological properties, efficacy, and safety data.
Main Results:
- Bedaquiline and delamanid demonstrate promising efficacy against resistant pulmonary TB in adults.
- These drugs possess unique mechanisms of action, distinct from older anti-TB agents.
- Potential cardiologic side effects, such as QT-interval prolongation, require monitoring.
Conclusions:
- Bedaquiline and delamanid represent significant advancements in treating resistant TB.
- Further pediatric studies are crucial to confirm efficacy and safety in younger populations.
- Consideration of drug interactions is vital due to the long treatment duration for resistant TB.
Keywords:
bedaquilinechildrendelamanidextensively drug-resistant tuberculosismultidrug-resistant tuberculosispediatric tuberculosistuberculosisMore Related Videos
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