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Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
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Presumed perinatal ischemic stroke: A review.

Sebastián Gacio1, Francisco Muñoz Giacomelli2, Francisco Klein2

  • 1Neurología Infantil, Instituto de Neurociencias, Universidad Favaloro.

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Summary
This summary is machine-generated.

Perinatal stroke risk is highest in newborns, but diagnosis is often delayed due to subtle symptoms or imaging limitations. Presumed perinatal ischemic stroke highlights significant underdiagnosis of early stroke events.

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Area of Science:

  • Neurology
  • Pediatrics
  • Vascular Medicine

Background:

  • Stroke risk is notably high during the perinatal period.
  • Neonatal brain imaging may lack sensitivity or infants may present with no clear signs, delaying stroke diagnosis.
  • Presumed perinatal ischemic stroke (PPIS) refers to neurological findings in infants diagnosed later.

Purpose of the Study:

  • To investigate the diagnostic challenges and implications of presumed perinatal ischemic stroke.
  • To highlight the underdiagnosis of perinatal stroke.

Main Methods:

  • Review of clinical presentations and neuroimaging findings in infants with delayed stroke diagnosis.
  • Analysis of cases classified as presumed perinatal ischemic stroke.

Main Results:

  • Delayed diagnosis of perinatal stroke is common, often identified months or years after birth.
  • Presumed perinatal ischemic stroke confirms a significant level of underdiagnosis in perinatal stroke.
  • This condition aids in understanding perinatal ischemic vascular disease.

Conclusions:

  • Early recognition of perinatal stroke is crucial but challenging.
  • Presumed perinatal ischemic stroke underscores the need for improved diagnostic strategies.
  • Further research is needed to improve the detection and management of perinatal ischemic vascular disease.