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Updated: Apr 5, 2026

Retroviral Transduction of Helper T Cells as a Genetic Approach to Study Mechanisms Controlling their Differentiation and Function
Published on: November 4, 2016
Approaches to Study Human T Cell Development
Anne-Catherine Dolens1, Inge Van de Walle, Tom Taghon
1The Department of Clinical Chemistry, Microbiology and Immunology, Faculty of Medicine and Health Sciences, Ghent University Hospital, Ghent University, De Pintelaan 185 Blok A-4, 9000, Ghent, Belgium.
Abstract:
Not only is human T cell development characterized by unique changes in surface marker expression, but it also requires specific growth factors and conditions to mimic and study T cell development in vitro. In this chapter, we provide an overview of the specific aspects that need attention when performing T cell differentiation cultures with human progenitors.
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